RTI-32

In today's world, the importance of RTI-32 is evident in all walks of life. Whether in the world of business, politics, science or culture, RTI-32 plays a crucial role in the way people interact, inform each other, and make decisions. This is why it is essential to fully understand the impact that RTI-32 has on our society, as well as the possible implications that its influence could have in the future. In this article, we will explore the different aspects and perspectives related to RTI-32, with the aim of providing an overview and insight into its relevance in today's world.

RTI-32
Identifiers
  • Methyl (1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-azabicyclooctane-2-carboxylate
CAS Number
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H23NO2
Molar mass273.376 g·mol−1
3D model (JSmol)
  • CC1=CC=C(C=C1)2C3CC(2C(=O)OC)N3C
  • InChI=1S/C17H23NO2/c1-11-4-6-12(7-5-11)14-10-13-8-9-15(18(13)2)16(14)17(19)20-3/h4-7,13-16H,8-10H2,1-3H3/t13-,14+,15+,16-/m0/s1
  • Key:MMKZDDDDODERSJ-JJXSEGSLSA-N
  (verify)

(–)-2β-Carbomethoxy-3β-(4-tolyl)tropane (RTI-4229-32, tolpane) is a phenyltropane-based cocaine analogue that has similar properties in vitro to related drugs such as RTI-31.[1][2]

Comparison of Data
Compound DAT DA NET NA SERT 5HT ED50
Troparil 23 49.8 550 37.2 178 173 0.34
RTI-32 1.7 7.02 36 8.42 23 19.4 0.31
RTI-31 1.1 3.68 22 5.86 4.0 5.0 0.13
3'4'-xylyl 0.43 unknown 44 unknown 2.42 unknown

See also

References

  1. ^ Remy P, Doder M, Lees A, Turjanski N, Brooks D (June 2005). "Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system". Brain. 128 (Pt 6): 1314–22. doi:10.1093/brain/awh445. PMID 15716302.
  2. ^ Xu L, Izenwasser S, Katz JL, Kopajtic T, Klein-Stevens C, Zhu N, et al. (March 2002). "Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters". Journal of Medicinal Chemistry. 45 (6): 1203–10. doi:10.1021/jm010453u. PMID 11881989.