RIC8A

In today's article we are going to talk about RIC8A, a topic that has been the subject of great interest in recent years. RIC8A is a topic that affects a large number of people around the world, so it is important to know all the aspects related to it. In this article we are going to explore different aspects of RIC8A, from its history and evolution, to its implications today. In addition, we will address different perspectives and opinions about RIC8A, with the aim of offering a comprehensive view on this topic. Join us on this journey of discovery and learning about RIC8A.

Protein-coding gene in the species Homo sapiens

RIC8A
Identifiers
Aliases	RIC8A, RIC8, RIC8 guanine nucleotide exchange factor A
External IDs	OMIM: 609146; MGI: 2141866; HomoloGene: 23331; GeneCards: RIC8A; OMA:RIC8A - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 207,708 bp[1] End 215,113 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F4 Start 140,436,870 bp[2] End 140,444,285 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ventricular zone granulocyte ganglionic eminence smooth muscle tissue gallbladder anterior pituitary prefrontal cortex right coronary artery decidua Top expressed in Paneth cell Rostral migratory stream aortic valve supraoptic nucleus external carotid artery fossa ascending aorta internal carotid artery condyle conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity guanyl-nucleotide exchange factor activity G-protein alpha-subunit binding Cellular component cytoplasm plasma membrane membrane Biological process visual learning G protein-coupled receptor signaling pathway positive regulation of GTPase activity cell migration involved in gastrulation cell-cell adhesion involved in gastrulation vasculature development in utero embryonic development adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway gastrulation response to light stimulus basement membrane organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60626 101489 Ensembl ENSG00000177963 ENSMUSG00000025485 UniProt Q9NPQ8 Q3TIR3 RefSeq (mRNA) NM_001286134 NM_021932 NM_001386941 NM_001386942 NM_053194 RefSeq (protein) NP_001273063 NP_068751 NP_444424 Location (UCSC) Chr 11: 0.21 – 0.22 Mb Chr 7: 140.44 – 140.44 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Resistance to inhibitors of cholinesterase-8A (Ric-8A), also known as Synembryn-A, is a protein that in humans is encoded by the RIC8A gene.^[5][6][7]

Interactions

RIC8A has been shown to interact with GNAO1,^[8] GNA13,^[9][8] GNAQ,^[8][10] GNAS complex locus,^[10] GNAI2,^[8] GNAI1^[8] and GNAI3.^[8]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000177963 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000025485 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Miller KG, Emerson MD, McManus JR, Rand JB (Sep 2000). "RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system". Neuron. 27 (2): 289–99. doi:10.1016/S0896-6273(00)00037-4. PMC 4704990. PMID 10985349.
6. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
7. ^ "Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)".
8. ^ ^{a b c d e f} Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. 278 (10). United States: 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430.
9. ^ Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011). "Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization". The Journal of Biological Chemistry. 286 (35): 31055–61. doi:10.1074/jbc.M111.253427. PMC 3162464. PMID 21771786.
10. ^ ^{a b} Klattenhoff, Carla; Montecino Martín; Soto Ximena; Guzmán Leonardo; Romo Ximena; García María Angeles; Mellstrom Britt; Naranjo José Ramón; Hinrichs María Victoria; Olate Juan (May 2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol". J. Cell. Physiol. 195 (2). United States: 151–7. doi:10.1002/jcp.10300. hdl:10533/174200. ISSN 0021-9541. PMID 12652642. S2CID 84975473.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tall GG, Krumins AM, Gilman AG (2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.
• Klattenhoff C, Montecino M, Soto X, et al. (2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol". J. Cell. Physiol. 195 (2): 151–7. doi:10.1002/jcp.10300. hdl:10533/174200. PMID 12652642. S2CID 84975473.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Nishimura A, Okamoto M, Sugawara Y, et al. (2006). "Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells". Genes Cells. 11 (5): 487–98. doi:10.1111/j.1365-2443.2006.00959.x. PMID 16629901. S2CID 27425469.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Wang SC, Lai HL, et al. (2007). "Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor". Biochem J. 406 (3): 383–8. doi:10.1042/BJ20070512. PMC 2049038. PMID 17593019.

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