RAB8A

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RAB8A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRAB8A, MEL, RAB8, member RAS oncogene family
External IDsOMIM: 165040; MGI: 96960; HomoloGene: 100934; GeneCards: RAB8A; OMA:RAB8A - orthologs
Orthologs
SpeciesHumanMouse
Entrez

4218

17274

Ensembl

ENSG00000167461

ENSMUSG00000003037

UniProt

P61006

P55258

RefSeq (mRNA)

NM_005370

NM_023126

RefSeq (protein)

NP_005361
NP_005361.2

NP_075615

Location (UCSC)Chr 19: 16.11 – 16.13 MbChr 8: 72.92 – 72.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.[5][6][7]

Function

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrated. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.[7]

Interactions

RAB8A has been shown to interact with Optineurin[8] and MAP4K2.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167461 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003037 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nimmo ER, Sanders PG, Padua RA, Hughes D, Williamson R, Johnson KJ (Aug 1991). "The MEL gene: a new member of the RAB/YPT class of RAS-related genes". Oncogene. 6 (8): 1347–51. PMID 1886711.
  6. ^ Huber LA, Pimplikar S, Parton RG, Virta H, Zerial M, Simons K (Oct 1993). "Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane". The Journal of Cell Biology. 123 (1): 35–45. doi:10.1083/jcb.123.1.35. PMC 2119815. PMID 8408203.
  7. ^ a b "Entrez Gene: RAB8A RAB8A, member RAS oncogene family".
  8. ^ Hattula K, Peränen J (2000). "FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis". Current Biology. 10 (24): 1603–6. Bibcode:2000CBio...10.1603H. doi:10.1016/S0960-9822(00)00864-2. PMID 11137014. S2CID 12836037.
  9. ^ Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD (May 1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 5151–5. Bibcode:1996PNAS...93.5151R. doi:10.1073/pnas.93.10.5151. PMC 39423. PMID 8643544.

Further reading


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