Otamixaban

In this article, we will explore the topic of Otamixaban in depth, analyzing its origins, evolution, and relevance today. Otamixaban is a topic that has aroused great interest in various fields, from science to popular culture. Throughout history, Otamixaban has played a fundamental role in society, influencing different aspects of modern life. Through this article, we will try to shed light on the most relevant aspects of Otamixaban, with the aim of providing a comprehensive and updated view on this topic.

Otamixaban
Clinical data
ATC code
  • none
Identifiers
  • Methyl (2R,3R)-2-{3-benzyl}-3-{amino}butanoate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC25H26N4O4
Molar mass446.507 g·mol−1
3D model (JSmol)
  • O=C(OC)(Cc1cc(C(=)N)ccc1)(NC(=O)c3ccc(c2cc()cc2)cc3)C
  • InChI=1S/C25H26N4O4/c1-16(22(25(31)33-2)15-17-4-3-5-21(14-17)23(26)27)28-24(30)20-8-6-18(7-9-20)19-10-12-29(32)13-11-19/h3-14,16,22H,15H2,1-2H3,(H3,26,27)(H,28,30)/t16-,22-/m1/s1 checkY
  • Key:PFGVNLZDWRZPJW-OPAMFIHVSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Otamixaban (INN) is an experimental injectable anticoagulant direct factor Xa inhibitor[1] that was investigated for the treatment for acute coronary syndrome. In 2013, Sanofi announced that it had ended development of the drug candidate after poor performance in a Phase III clinical trial.[2][3]

References

  1. ^ Guertin KR, Choi YM (2007). "The discovery of the Factor Xa inhibitor otamixaban: from lead identification to clinical development". Curr. Med. Chem. 14 (23): 2471–81. doi:10.2174/092986707782023659. PMID 17979700.
  2. ^ "AstraZeneca, Sanofi Cut Programs". Chemical & Engineering News. 91 (23). American Chemical Society: 17. June 10, 2013. Sanofi is ending development on two compounds, the anticancer compound iniparib and the anticoagulant otamixaban, both of which flunked Phase III studies.
  3. ^ "Sanofi's Investigational Iniparib, Otamixaban Fail To Meet Goals, Ends Programs". RTT news. Retrieved 11 April 2014.
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