Nef synthesis

Nef synthesis's theme is one that has captured the attention of millions around the world. From his impact on society to his influence on popular culture, Nef synthesis has left an indelible mark on history. In this article we will explore in depth the most relevant aspects of Nef synthesis, from its origins to its evolution over time. Through exclusive interviews, extensive research and detailed analysis, we will reveal the true importance of Nef synthesis and its impact on the modern world.

Not to be confused with Nef isocyanide reaction or Nef reaction.
Nef synthesis
Named after John Ulric Nef
Reaction type Coupling reaction
Identifiers
RSC ontology ID RXNO:0000506

In organic chemistry, Nef synthesis is the addition of sodium acetylides to aldehydes and ketones to yield propargyl alcohols.[1][2][3][4][5][6] It is named for John Ulric Nef, who discovered the reaction in 1899.

This process is often erroneously referred to as the Nef reaction,[4][7][8][9] which is an unrelated chemical transformation discovered by the same chemist.

See also

References

  1. ^ Nef, John Ulric (1899). "Ueber das Phenylacetylen, seine Salze und seine Halogensubstitutionsproducte". Justus Liebigs Annalen der Chemie. 308 (3): 264–328. doi:10.1002/jlac.18993080303.
  2. ^ Johnson, A. W. (1946). The Chemistry of the Acetylenic Compounds (1st ed.). London: Arnold. p. 11. ISBN 978-0-598-99095-2. Retrieved 25 February 2016. {{cite book}}: ISBN / Date incompatibility (help)
  3. ^ Hurd, Charles D.; McPhee, Warren D. (1947). "Condensation of Acetylene with Acetone and Other Ketones". Journal of the American Chemical Society. 69 (2): 239–241. doi:10.1021/ja01194a018.
  4. ^ a b Oroshnik, William; Mebane, Alexander D. (1949). "The Nef Reaction with α,β-Unsaturated Ketones". Journal of the American Chemical Society. 71 (6): 2062–2065. doi:10.1021/ja01174a048.
  5. ^ Raphael, Ralph Alexander (1955). Acetylenic Compounds in Organic Synthesis (1st ed.). London: Butterworths. p. 10. Retrieved 25 February 2016.
  6. ^ Coffman, Donald D. (1940). "Dimethylethhynylcarbinol". Organic Syntheses. 40: 20. doi:10.15227/orgsyn.020.0040.
  7. ^ Viehe, Heinz Günter (1969). Chemistry of Acetylenes (1st ed.). New York: Marcel Dekker, inc. pp. 207–241. doi:10.1002/ange.19720840843.
  8. ^ Wolfrom, Melville L. (1960). "John Ulric Nef: 1862—1915". Biographical Memoirs (PDF) (1st ed.). Washington, DC: National Academy of Sciences. p. 218. Retrieved 24 February 2016.
  9. ^ Smith, Michael B.; March, Jerry (2007). "Chapter 16. Addition to Carbon–Hetero Multiple Bonds". March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (6th ed.). Hoboken, New Jersey: John Wiley & Sons, Inc. pp. 1359–1360. doi:10.1002/9780470084960.ch16. ISBN 9780471720911.


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