Lampalizumab

Nowadays, Lampalizumab is a topic that has gained great relevance in contemporary society. The importance of Lampalizumab has been widely discussed and studied by experts in different disciplines, arousing the interest of people of all ages and backgrounds. In this article, we will thoroughly explore the impact of Lampalizumab on our daily lives, analyzing its implications in various areas of society. From its influence on popular culture to its relevance in the global economy, Lampalizumab has become a central topic of debate and research. Join us on this journey through the different facets of Lampalizumab and discover its importance in today's world.

Lampalizumab
Monoclonal antibody
TypeFab fragment
SourceHumanized (from mouse)
TargetCFD
Clinical data
Routes of
administration		Intravitreal
ATC code
  • none
Identifiers
CAS Number
IUPHAR/BPS
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC2068H3214N546O676S13
Molar mass46958.39 g·mol−1

Lampalizumab (INN) is an antigen-binding fragment of a humanized monoclonal antibody that binds to complement factor D; it was developed as a potential treatment of geographic atrophy (atrophy of the retinal cells, retinal pigment epithelium, and choriocapillaris) secondary to age-related macular degeneration.[1][2]

One of the two Phase 3 clinical trials (Spectri) was interrupted on September 8, 2017 due to failure to meet primary end point.[3] The second Phase 3 clinical trial (Chroma) also failed to meet its primary end point.[4]

These two failures have called into question whether complement inhibition is a sound strategy for geographic atrophy.[5]

References

  1. ^ World Health Organization (2012). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 107" (PDF). WHO Drug Information. 26 (2).
  2. ^ "Statement On A Nonproprietary Name Adopted By The USAN Council - Lampalizumab" (PDF). American Medical Association.
  3. ^ "Roche provides update on first lampalizumab phase III study for geographic atrophy, an advanced form of age-related macular degeneration". www.roche.com. Retrieved 2017-09-14.
  4. ^ "Statement on Chroma Study". www.roche.com. Retrieved 2017-11-10.
  5. ^ Dolgin E (November 2017). "Age-related macular degeneration foils drugmakers". Nature Biotechnology. 35 (11): 1000–1001. doi:10.1038/nbt1117-1000. PMID 29121027. S2CID 9682962.
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