GNA14

Today, GNA14 is a topic of great relevance in society. Throughout history, GNA14 has impacted people's lives in various ways, influencing their decisions, their thoughts and their way of acting. From a social approach, GNA14 has been the subject of debates and discussions in different areas, generating conflicting opinions and diverse positions. This is why it is essential to delve deeper into the study of GNA14, in order to understand its importance and impact on daily life. In this article, we will explore the different facets of GNA14, analyzing its historical context, its relevance today, and possible implications for the future.

Protein-coding gene in the species Homo sapiens

GNA14
Identifiers
Aliases	GNA14, G protein subunit alpha 14, HG1I
External IDs	OMIM: 604397; MGI: 95769; HomoloGene: 68386; GeneCards: GNA14; OMA:GNA14 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.2 Start 77,423,079 bp[1] End 77,648,322 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 11.29 cM Start 16,413,126 bp[2] End 16,588,184 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte bronchial epithelial cell testicle C1 segment smooth muscle tissue left lobe of thyroid gland tail of epididymis olfactory zone of nasal mucosa right lobe of thyroid gland body of uterus Top expressed in lumbar spinal ganglion vestibular membrane of cochlear duct zygote secondary oocyte facial motor nucleus primary oocyte left colon gastrula right kidney stria vascularis More reference expression data BioGPS n/a
Gene ontology Molecular function guanyl nucleotide binding nucleotide binding GTP binding protein binding metal ion binding G protein-coupled receptor binding GTPase activity signal transducer activity G-protein beta/gamma-subunit complex binding Cellular component plasma membrane extracellular exosome heterotrimeric G-protein complex Biological process platelet activation phospholipase C-activating dopamine receptor signaling pathway signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9630 14675 Ensembl ENSG00000156049 ENSMUSG00000024697 UniProt O95837 P30677 RefSeq (mRNA) NM_004297 NM_008137 RefSeq (protein) NP_004288 NP_032163 Location (UCSC) Chr 9: 77.42 – 77.65 Mb Chr 19: 16.41 – 16.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein subunit alpha-14 is a protein that in humans is encoded by the GNA14 gene.^[5][6][7] G₁₄α is a member of the Gq alpha subunit family, and functions as a constituent of a heterotrimeric G protein in cell signal transduction.

See also

• Gq alpha subunit
• Heterotrimeric G protein

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000156049 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000024697 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014. S2CID 31888533.
6. ^ "Entrez Gene: GNA14 G protein subunit alpha 14 [ Homo sapiens (human) ]". Retrieved 2019-07-25.
7. ^ GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-14; GNA14 at OMIM. Retrieved JULY 25, 2019.