Efavaleukin alfa

In the modern world, Efavaleukin alfa has become a topic of increasing interest to a wide spectrum of people. From experts in the field to those who know little about the subject, Efavaleukin alfa has captured everyone's attention. With the rapid evolution of technology and society, Efavaleukin alfa has become relevant in various aspects of daily life. In this article, we will explore in depth the complexities and dimensions of Efavaleukin alfa, analyzing its impact in different areas and offering a comprehensive overview of this intriguing issue.

Efavaleukin alfa is an experimental drug that works as an interleukin-2 "mutein Fc fusion protein that preferentially binds the high-affinity IL-2 receptor alpha chain (CD25) to selectively promote Treg expansion".[1] It is developed to treat systemic lupus erythematosus (SLE).[2][3][4]

References

  1. ^ Sarkar, N.; Hu, X.; Tchao, N.; Furie, R.; Kivitz, A.; Cohen, S.; Gorski, K. (1 June 2023). "Op0140 Regulatory T Cell Defects in Sle and Therapy with a Novel Il-2 Mutein: Phase 1 Clinical Results with Efavaleukin Alfa". Annals of the Rheumatic Diseases. 82 (Suppl 1): 92–93. doi:10.1136/annrheumdis-2023-eular.369. ISSN 0003-4967.
  2. ^ Cully, Megan (6 August 2021). "T cell-regulating therapies for autoimmune diseases take FDA rejection in stride". Nature Reviews Drug Discovery. 20 (9): 655–657. doi:10.1038/d41573-021-00137-0.
  3. ^ Garces, Sandra; Karis, Elaine; Merrill, Joan T; Askanase, Anca D; Kalunian, Kenneth; Mo, May; Milmont, Cassandra E (July 2023). "Improving resource utilisation in SLE drug development through innovative trial design". Lupus Science & Medicine. 10 (2): e000890. doi:10.1136/lupus-2022-000890.
  4. ^ Tchao, N.; Sarkar, N.; Hu, X.; Zhang, R.; Milmont, C.; Jin, Y. Shi; Chow, V.; Kroenke, M.; Gorski, K.; Furie, R.; Kivitz, A.; Cohen, S. (1 June 2022). "Ab0432 Efavaleukin Alfa, a Novel Il-2 Mutein, Selectively Expands Regulatory T Cells in Patients with Sle: Final Results of a Phase 1b Multiple Ascending Dose Study". Annals of the Rheumatic Diseases. 81 (Suppl 1): 1343–1344. doi:10.1136/annrheumdis-2022-eular.2244. ISSN 0003-4967.