Dichlorochromopyrrolate synthase
Appearance
move to sidebar
hide
Dichlorochromopyrrolate synthase (EC 1.21.3.9, RebD, dichlorochromopyrrolic acid synthase) is an enzyme with systematic name 2-imino-3-(7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming). This enzyme catalyses the following chemical reaction
4 2-imino-3-(7-chloroindol-3-yl)propanoate + O2
⇌
{\displaystyle \rightleftharpoons }
![{\displaystyle \rightleftharpoons }](https://wikimedia.org/api/rest_v1/media/math/render/svg/1c37b981df851b9e54e489e017b1481e37d418f3)
2
dichlorochromopyrrolate + 2 NH3 + 2 H2O
This enzyme catalyses a step in the biosynthesis of rebeccamycin.
References
- ^ Nishizawa T, Grüschow S, Jayamaha DH, Nishizawa-Harada C, Sherman DH (January 2006). "Enzymatic assembly of the bis-indole core of rebeccamycin". Journal of the American Chemical Society. 128 (3): 724–5. doi:10.1021/ja056749x. PMID 16417354.
- ^ Howard-Jones AR, Walsh CT (December 2005). "Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD". Biochemistry. 44 (48): 15652–63. CiteSeerX 10.1.1.537.5773. doi:10.1021/bi051706e. PMID 16313168.
External links
Enzymes |
---|
Activity |
|
---|
Regulation |
|
---|
Classification |
|
---|
Kinetics |
|
---|
Types |
|
---|