Corrinoid

In today's world, Corrinoid has acquired crucial relevance in various areas of daily life. From its impact on public health to its influence on the global economy, Corrinoid has become an inevitable topic of conversation. Throughout history, Corrinoid has played a fundamental role in society, shaping our beliefs, behaviors and decisions. In this article, we will explore the different facets of Corrinoid and its impact on the world, analyzing its evolution over time and its relevance in the present. Through deep and insightful analysis, we seek to shed light on the role Corrinoid plays in our lives and how it has come to define our reality.

Corrin ring, numbered according to the 1975 IUPAC standard. Note that for consistency with the porphyrin numbering system, there is no 20 position. Positions 21-24 were numbered 20-23 in earlier literature.[1]
Vitamin B12 (cyanocobalamin)

Corrinoids are a group of compounds based on the skeleton of corrin, a cyclic system containing four pyrrole rings similar to porphyrins.[2] These include compounds based on octadehydrocorrin, which has the trivial name corrole.[3]

The cobalamins (vitamin B12) are the best known members of the group. Other prominent examples include cobyrinic acid and its hexaamide cobyric acid; cobinic acid and its hexaamide cobinamide; cobamic acid and cobamide.

Compounds containing the "Cob-" prefix (not corrin) are cobalt derivatives, and may include an oxidation state, as in "Cob(II)alamin". When cobalt is replaced by another metal or hydrogen, the name changes accordingly, as in ferrobamic acid or hydrogenobamic acid.

Reactions with cyanide

A solution of aquacyano-corrinoids, such as cobalamin or cobinamide, reacts with free cyanide in an aqueous sample. The binding of cyanide to the corrinoid cobalt center leads to a color change from orange to violet.[4] Quantification of the cyanide content is feasible by UV-vis spectroscopy.[5][6] Absorption of the corrinoid on a solid phase,[7] allows detection of cyanide even in colored samples, rendering this method appropriate for the analysis of cyanide in water, wastewater, blood, and food.[8][9] Furthermore, this technology is non-toxic and considerably less prone to interference than the pyridine-barbituric acid colorimetry method.

References

  1. ^ Dorothy Crowfoot Hodgkin (1965-11-16). "The Structure of the Corrin Nucleus from X-ray Analysis". Proceedings of the Royal Society of London. Series A, Mathematical and Physical Sciences. 288 (1414): 294–305. Bibcode:1965RSPSA.288..294H. doi:10.1098/rspa.1965.0219. JSTOR 2415001. S2CID 95235740.
  2. ^ Cracan, Valentin; Banerjee, Ruma (2013). "Chapter 10 Cobalt and Corrinoid Transport and Biochemistry". In Banci, Lucia (ed.). Metallomics and the Cell. Metal Ions in Life Sciences. Vol. 12. Springer. pp. 333–374. doi:10.1007/978-94-007-5561-1_10. ISBN 978-94-007-5560-4. PMID 23595677. electronic-book ISBN 978-94-007-5561-1 ISSN 1559-0836 electronic-ISSN 1868-0402
  3. ^ "The Nomenclature of Corrinoids: Recommendations 1975". IUPAC-IUB Commission on Biochemical Nomenclature (CBN). 1975. Archived from the original on 2012-10-28. Retrieved 2006-06-19.
  4. ^ Pratt, J.M. (1972). Inorganic Chemistry of Vitamin B12. Academic Press. p. 44.
  5. ^ Zelder, F.H. (2008). "Specific Colorimetric Detection of Cyanide Triggered by a Conformational Switch in Vitamin B12". Inorganic Chemistry. 47 (4): 1264–1266. doi:10.1021/ic702368b. PMID 18205304.
  6. ^ Mannel-Croise, Zelder (2009). "Side chains of cobalt corrinoids control the sensitivity and selectivity in the colorimetric detection of cyanide". Inorganic Chemistry. 48 (4): 1272–1274. doi:10.1021/ic900053h. PMID 19161297.
  7. ^ Mannel-Croise, Zelder (2012). "Complex samples cyanide detection with immobilized corrinoids". ACS Applied Materials & Interfaces. 4 (2): 725–729. doi:10.1021/am201357u. PMID 22211318.
  8. ^ Tivana, Da Cruz Francisco, Zelder, Bergenståhl, Dejmek (2014). "Straightforward rapid spectrophotometric quantification of total cyanogenic glycosides in fresh and processed cassava products" (PDF). Food Chemistry. 158: 20–27. doi:10.1016/j.foodchem.2014.02.066. PMID 24731309.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. ^ Mannel-Croise, Zelder (2012). "Rapid visual detection of blood cyanide" (PDF). Analytical Methods. 4 (9): 2632–2634. doi:10.1039/c2ay25595b. S2CID 96719554.