CDKL2

In this article, the topic of CDKL2 will be addressed from different perspectives and discussions. CDKL2 is a topic that has sparked interest and debate in various areas, generating great expectations among experts and the general public. In the following lines, the implications, repercussions and possible solutions related to CDKL2 will be explored, in order to offer a comprehensive and enlightening vision on this topic. Furthermore, different opinions and approaches will be taken into account to enrich the analysis and provide a multidimensional view of CDKL2.

Protein-coding gene in humans

CDKL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AAA, 4BBM
Identifiers
Aliases	CDKL2, KKIAMRE, P56, cyclin dependent kinase like 2
External IDs	OMIM: 603442; MGI: 1858227; HomoloGene: 55793; GeneCards: CDKL2; OMA:CDKL2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.1 Start 75,576,496 bp[1] End 75,630,716 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E2 Start 92,006,074 bp[2] End 92,043,883 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus postcentral gyrus superior frontal gyrus testicle primary visual cortex entorhinal cortex lower lobe of lung prefrontal cortex Top expressed in barrel cortex lumbar spinal ganglion spermatocyte facial motor nucleus seminiferous tubule olfactory epithelium spermatid vestibular sensory epithelium zygote Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein serine/threonine kinase activity ATP binding kinase activity cyclin-dependent protein serine/threonine kinase activity Cellular component cytoplasm centrosome nucleus Biological process protein phosphorylation sex differentiation phosphorylation signal transduction regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8999 53886 Ensembl ENSG00000138769 ENSMUSG00000029403 UniProt Q92772 Q9QUK0 RefSeq (mRNA) NM_003948 NM_001330724 NM_001276315 NM_016912 NM_177270 RefSeq (protein) NP_001317653 NP_003939 NP_001263244 NP_058608 NP_796244 Location (UCSC) Chr 4: 75.58 – 75.63 Mb Chr 5: 92.01 – 92.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene.^[5][6]

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus.^[6]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000138769 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000029403 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Taglienti CA, Wysk M, Davis RJ (Feb 1997). "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE". Oncogene. 13 (12): 2563–74. PMID 9000130.
6. ^ ^{a b} "Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)".

External links

• Human CDKL2 genome location and CDKL2 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q92772 (Cyclin-dependent kinase-like 2) at the PDBe-KB.

Further reading

• Marracci GH, Marquardt WE, Strehlow A, et al. (2006). "Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck)". Biochem. Biophys. Res. Commun. 344 (3): 963–971. doi:10.1016/j.bbrc.2006.03.172. PMID 16631599.
• Sarkar SN, Peters KL, Elco CP, et al. (2004). "Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling". Nat. Struct. Mol. Biol. 11 (11): 1060–1067. doi:10.1038/nsmb847. PMID 15502848. S2CID 6869429.
• Tao J, Van Esch H, Hagedorn-Greiwe M, et al. (2005). "Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation". Am. J. Hum. Genet. 75 (6): 1149–1154. doi:10.1086/426460. PMC 1182152. PMID 15499549.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Marcilla A, Rivero-Lezcano OM, Agarwal A, Robbins KC (1995). "Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors". J. Biol. Chem. 270 (16): 9115–9120. doi:10.1074/jbc.270.16.9115. PMID 7721825.

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