Actisomide

In this article, we will explore the fascinating world of Actisomide, which has left its mark on history, culture and society. Actisomide has been the subject of debates, studies and interpretations over the years, awakening the curiosity and interest of those who immerse themselves in its universe. With a relevance that transcends the barriers of time, Actisomide continues to be a topic of discussion and reflection today. Through this article, we will delve into the different aspects surrounding Actisomide, analyzing its impact and meaning in various areas.

Actisomide
Names
Preferred IUPAC name
(4R,4aR)-4-{2-ethyl}-1-methyl-4-phenyl-4,4a,5,6,7,8-hexahydro-3H-pyridopyrimidin-3-one
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
KEGG
MeSH C051827
UNII
  • InChI=1S/C23H35N3O/c1-17(2)25(18(3)4)16-14-23(20-11-7-6-8-12-20)21-13-9-10-15-26(21)19(5)24-22(23)27/h6-8,11-12,17-18,21H,9-10,13-16H2,1-5H3/t21-,23-/m1/s1
    Key: QAHRRCMLXFLZTF-FYYLOGMGSA-N
  • CC1=NC(=O)(2N1CCCC2)(CCN(C(C)C)C(C)C)C3=CC=CC=C3
Properties
C23H35N3O
Molar mass 369.553 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).

Actisomide is an antiarrhythmic drug[1] that is made from disopyramide.

Synthesis

Actisomide synthesis:[2]

References

  1. ^ Cook, CS; Rozek, LF; Stolzenbach, J; Anderson, S; Schoenhard, GL; Karim, A (1993). "Pharmacokinetics of a novel antiarrhythmic drug, actisomide". Pharmaceutical Research. 10 (3): 427–33. doi:10.1023/a:1018900725050. PMID 8464818. S2CID 19083868.
  2. ^ Chorvat, Robert J.; Prodan, Kathleen A.; Adelstein, Gilbert W.; Rydzewski, Robert M.; McLaughlin, Kathleen T.; Stamm, Margarete H.; Frederick, Leo G.; Schniepp, Henry C.; Stickney, Janice L. (1985). "Synthesis and structure-activity relationships of a new series of antiarrhythmic agents: 4,4-disubstituted hexahydro-3H-pyridopyrimidin-3-ones and related compounds". Journal of Medicinal Chemistry. 28 (9): 1285–91. doi:10.1021/jm00147a029. PMID 4032431.


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