ATP1B1
In today's world, ATP1B1 is an issue that has become increasingly relevant in society. Whether due to its impact on health, its influence on popular culture or its importance in the global economy, ATP1B1 has become a focus of attention for experts, academics and the general public. Throughout history, ATP1B1 has been the subject of debate and discussion, generating endless opinions and perspectives. In this article, we will explore the different facets of ATP1B1, analyzing its evolution over time and its role today. From its impact on technology to its relevance in the political sphere, ATP1B1 continues to be a topic of universal interest that continues to generate interest and analysis.
Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene.[5]
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+-ATPases. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+-ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000143153 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026576 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide".
Further reading
- Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na,K-ATPase". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 38: 37–89. doi:10.1016/S0079-6603(08)60708-4. ISBN 978-0-12-540038-1. PMID 2158121.
- Oakey RJ, Watson ML, Seldin MF (1993). "Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA". Hum. Mol. Genet. 1 (8): 613–20. doi:10.1093/hmg/1.8.613. PMID 1301170.
- Martin-Vasallo P, Dackowski W, Emanuel JR, Levenson R (1989). "Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression". J. Biol. Chem. 264 (8): 4613–8. doi:10.1016/S0021-9258(18)83787-5. PMID 2538450.
- Ushkaryov YuA, Monastyrskaya GS, Broude NE, et al. (1990). "Human Na+,K+-ATPase genes. Beta-subunit gene family contains at least one gene and one pseudogene". FEBS Lett. 257 (2): 439–42. doi:10.1016/0014-5793(89)81591-1. PMID 2555225. S2CID 13623201.
- Lane LK, Shull MM, Whitmer KR, Lingrel JB (1990). "Characterization of two genes for the human Na,K-ATPase beta subunit". Genomics. 5 (3): 445–53. doi:10.1016/0888-7543(89)90008-6. PMID 2559024.
- Yang-Feng TL, Schneider JW, Lindgren V, et al. (1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.
- Sverdlov ED, Broude NE, Sverdlov VE, et al. (1987). "Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism". FEBS Lett. 221 (1): 129–33. doi:10.1016/0014-5793(87)80366-6. PMID 2887455. S2CID 32756405.
- Kawakami K, Nojima H, Ohta T, Nagano K (1986). "Molecular cloning and sequence analysis of human Na,K-ATPase beta-subunit". Nucleic Acids Res. 14 (7): 2833–44. doi:10.1093/nar/14.7.2833. PMC 339706. PMID 3008098.
- Coca-Prados M, Fernández-Cabezudo MJ, Sánchez-Torres J, et al. (1996). "Cell-specific expression of the human Na+,K+-ATPase beta 2 subunit isoform in the nonpigmented ciliary epithelium". Invest. Ophthalmol. Vis. Sci. 36 (13): 2717–28. PMID 7499094.
- Ruiz A, Bhat SP, Bok D (1995). "Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium". Gene. 155 (2): 179–84. doi:10.1016/0378-1119(94)00812-7. PMID 7536695.
- Mobasheri A, Oukrif D, Dawodu SP, et al. (2001). "Isoforms of Na+, K+-ATPase in human prostate; specificity of expression and apical membrane polarization". Histol. Histopathol. 16 (1): 141–54. PMID 11193188.
- Gamaleĭ IA, Polozov IuS, Aksenov ND, et al. (2001). "". Tsitologiia. 43 (6): 602–12. PMID 11534180.
- Béguin P, Crambert G, Monnet-Tschudi F, et al. (2002). "FXYD7 is a brain-specific regulator of Na,K-ATPase α1–β isozymes". EMBO J. 21 (13): 3264–73. doi:10.1093/emboj/cdf330. PMC 125393. PMID 12093728.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. S2CID 581283.
- Fuller W, Eaton P, Bell JR, Shattock MJ (2004). "Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase". FASEB J. 18 (1): 197–9. doi:10.1096/fj.03-0213fje. PMID 14597563. S2CID 41768501.
- Li J, Codina J, Petroske E, et al. (2004). "The carboxy terminus of the colonic H+, K+-ATPase alpha-subunit is required for stable beta subunit assembly and function". Kidney Int. 65 (4): 1301–10. doi:10.1111/j.1523-1755.2004.00507.x. PMID 15086469.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wickham L, Benjannet S, Marcinkiewicz E, et al. (2005). "Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin". J. Neurochem. 92 (1): 93–102. doi:10.1111/j.1471-4159.2004.02840.x. PMID 15606899.
External links
- Human ATP1B1 genome location and ATP1B1 gene details page in the UCSC Genome Browser.
 | This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it. |